Association between diabetes and gastrointestinal disoders: results from the population based German National Cohort (NAKO)


Project leadVioletta Ptushkina

Approval date28.11.2023

Published date27.02.2024

SummaryType 2 diabetes is a global health issue with an increasing prevalence and disease burden (1). The International Diabetes Federation estimates the worldwide prevalence of diabetes with more than 537 million (10%) of people aged 20-79 years (2). This number is predicted to rise to 643 million by 2030 and 783 million by 2045 (2). People with diabetes are at increased risk of developing gastrointestinal diseases, such as gastroesophageal reflux (3), cholelithiasis (4), nonalcoholic fatty liver disease (5), and certain gastrointesti-nal cancers (6). However, the evidence regarding these associations lacks consistency (6,7,8). Moreover, there is a scarcity of data concerning the relationships between type 2 diabetes and the risk of gastritis and Crohn's disease (9). On the basis of the German National Cohort (NAKO, n=200.000), cross-sectional analyses will be conducted to determine the frequency of gastrointestinal disoders and to investigate its associated risk factors in people with diabetes. Identifying specific risk factors or predictors for the development of gastrointestinal disoders in individuals with diabetes is mandatory for early detection and intervention. Factors such as glycemic control, diabetes duration, obesity and other comorbidities will be studied to determine their impact on the occurrence and severity of gastrointestinal outcomes.

Keywords diabetes-mellitus diabetes-subgroups gastrointestinal-disoders

InstitutionsDeutsches Diabetes-Zentrum, Universitätsmedizin Greifswald, Deutsches Diabetes Zentrum Düsseldorf, Deutsches Diabetes-Zentrum (DDZ), Leibniz-Zentrum für Diabetes-Forschung an der Heinrich-Heine-Universität Düsseldorf

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