Evaluation and geographical comparison of the impact of cardiovascular risk factors on population attributable fractions (PAFs) and lifetime risks (LTRs) to assess cardiovascular disease (CVD) burden globally.

SchlüsselNAKO-653

ProjektleitungThiess Lorenz

Genehmigt am08.06.2022

Öffentlich seit27.02.2024

ZusammenfassungThe classical cardiovascular risk factors relate to cardiovascular disease (CVD) burden and consecutively to global cardiovascular health. This analysis works out differences in distribution and impact of modifiable risk factors by geographical region to improve CVD prevention. To do so, cause-specific stratified Cox models for CVD and death before CVD as competing risk will be computed. Additionally, populations-attributable fractions will be calculated based on modifiable risk factors: high blood pressure, BMI, smoking, diabetes and high non-HDL cholesterol. Thus far we included 120 cohorts from 8 regions: Africa, Australia, Eastern Europe, Western Europe, Middle East, North America, Central & South America, and Southeast Asia.

Schlüsselwörter CVD cardiovascular-diseases epidemiology population-attributable-fractions risk-factors

EinrichtungenUniversitäres Herz- und Gefäßzentrum Hamburg, Universitäres Herz- und Gefäßzentrum UKE Hamburg, Universitäres Herz & Gefäßzentrum Hamburg

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