Verknüpfte ProjekteNAKO-312

ZusammenfassungEpigenetic factors seem to influence the manifestation and course of multiple sclerosis (MS). In our first analyses of MS risk factors which were based on data of the data usage request NAKO-312, we observed an inverse association between breastfeeding compared to no breastfeeding and MS risk in men. In addition, compared to normal weight at the age of 18 years, overweight and obesity at the age of 18 years were associated with an increased MS risk. In recent, yet unpublished analyses of the StERKE nested case-control study, a low level of physical activity during adolescence (13 to 19 years), higher maternal age at first pregnancy, the cumulative number of stressful life events and the cumulative numer of childhood viral infections (chickenpox, mumps, rubella, pertussis, measles) as well as EBV were associated with an increased MS risk. In this follow-up data application, we now pursue two main objectives: First, we aim to analyse the associations between environmental as well as lifestyle factors and MS risk in more detail, including disease duration and impaired quality of life. We will take concurrent comorbidities into account and aim to disentangle conditions already prevalent at diagnosis and conditions emerging during the disease course. In this context, the metabolic load will be investigated by analysis of nutrition-related laboratory parameters (HBA1C, lipid analysis, OGTT) and systemic low-grade inflammation (hrCRP). Second, we will analyse physical and emotional functioning, cognition, as well as mental health in those with compared to persons without MS. In addition, we will examine special symptom domains, e.g., olfactory function, sleep and headache severity, that have rarely been addressed in MS epidemiological studies and assess their frequency and severity in relation to those without MS. The effects of risk factors, comorbidities and symptoms on quality of life, physical activity and participation, e.g., employment within the group of participants with MS will be evaluated. Data from the baseline survey of the German National Cohort (NAKO) will be used to answer the study questions on these manifestations of multiple sclerosis. Thereby, 860 MS cases will be included. StERKE data (L3 project) will be needed to have more disease specific information of impairments from the patient view.

Schlüsselwörter-

EinrichtungenUniversitätsklinikum Hamburg-Eppendorf, Universität Regensburg, Universitätsklinikum Hamburg-Eppendorf, Multiple Sclerosis Outpatient Health Care Center, Universitätsklinikum Heidelberg, UBC, Martin-Luther-Universität Halle-Wittenberg, Universitätsklinikum Düsseldorf, Institut für Epidemiologie der Universität Münster, Deutsches Institut für Ernährungsforschung