1.MRTCall - Individualized Functional Connectome Analyses: Validation and Application in the German National Cohort Study


Project leadPD Dr. Sophia Stöcklein

Approval date02.04.2019

Published date03.08.2020

SummaryThe capacity to identify the unique functional architecture of an individual’s brain is a critical step towards personalized medicine and understanding the neural basis of variations in hu-man cognition and behavior. Recently, we developed a novel cortical parcellation approach to accurately map the functional organization at the individual level using resting-state fMRI (Wang et al., 2015). Although the algorithm was tested across different subject populations and data types including task fMRI data, a validation by improved correspondence to neu-rocognitive parameters remains to be performed. Our aim which will be submitted via a follow-up proposal is to test if individualized function-al connectivity measures can predict neurocognitive performance more accurately than clas-sic atlas-based connectivity measures. Furthermore, we aim to supply the individualized con-nectivity measures back to the NAKO database, in order to enable other researchers to inves-tigate association of individualized connectivity measures with other parameters obtained within the NAKO framework.


InstitutionsKlinik und Poliklinik für Radiolgie, Harvard University, Fraunhofer MEVIS Bremen, Klinikum der Universität München, Forschungszentrum Jülich

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