SummaryDespite advancements in cardiovascular disease (CVD) treatment, inflammation remains a key factor in CVD mortality. Previous trials support the hypothesis that targeting inflammation reduces cardiovascular events. However, the routine use of hs-CRP for risk assessment varies among guidelines. The study titled "Inflammatory Biomarkers as Sensitive Predictors of Cardiovascular Risk: A Study-Population Wide Analysis of the German National Cohort (NAKO)" aims to investigate the role of inflammatory biomarkers, particularly high-sensitivity C-reactive protein (hs-CRP) and leukocyte counts, in predicting cardiovascular events. This study seeks to address this gap by evaluating the performance of biomarkers in predicting cardiovascular events across various demographic and clinical subgroups using data from the German National Cohort Study (NAKO). Additionally, the study will explore clinically relevant levels for hs-CRP and assess the predictive value of different inflammatory indices. The findings from this study are expected to provide valuable insights into improving risk prediction models and guiding preventive cardiology practices.

Keywords ASCVD HS-CRP Inflammation Preventive-Cardiology risk-prediction

InstitutionsUniklinik RWTH Aachen, Bundesinstitut für Bevölkerungsforschung, Fachbereich Medizin / Philipps-Universität Marburg