SummaryThe aim of this proposal is to investigate within the EU-funded IMMEDIATE project shared and non-shared inflammation signatures in the transition from health to disease in the domains of metabolic, cardiovascular, kidney and brain function in selected NAKO participants of the Berlin-North study center. Inflammatory profiles will be deeply characterized by OLINK® in baseline plasma samples of a subset of the NAKO Berlin-North study center participants (n=2,200), who have participated in the second examination (funding for these analyses is provided by Horizon Europe). Inflammatory profiles in baseline blood samples will be related to prospective changes in intermediary outcome variables (HbA1c, blood pressure, arterial stiffness and glomerular filtration rate). In addition, baseline inflammation signatures will be related to progression of brain damage as evidenced by neuroimaging which enables comprehensive quantitative assessment of brain white matter damage, grey and white matter atrophy and changes in functional connectivity over time. Lifestyle (anthropometry, physical activity, alcohol consumption, diet, smoking) and other (medical history, well-being, quality of life) factors associated with the identified shared and non-shared inflammation signatures will be investigated in order to explore the potential of personalized prevention. Finally, the gut microbiome profile will be quantified in stool samples (analyses funded by Horizon Europe for n=600 samples) and metabolomics profiling will be performed in blood samples (analyses funded by Horizon Europe for n=1,000 samples) for an integrative analysis on systems-overarching modulation pathways of chronic inflammation. Together, we will seize this opportunity of using multi-modality datasets to evaluate how the diet-microbiome-metabolite-immune axis influences health conditions as well as structural and homeostatic changes in the brain.

Keywords 1-H-NMR-Spektroskopie Ernährung Herz-Kreislauf-Gesundheit Inflammation Lebensstilfaktoren Mikrobiom Niere Stoffwechsel-Erkrankungen

InstitutionsMax Delbrück Centrum für Molekulare Medizine, ECRC, Max-Delbrück-Centrum für Molekulare Medizin, Berlin Insitute of Health at Charite Universitätsmedizin, Imperial College London, Universitätsmedizin Greifswald, Max Delbrück Center for Molecular Medicine, MDC Berlin-Buch Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft Robert-Rössle-Straße 10 13125 Berlin, Max-Delbrück-Centrum für Molekulare Medizin (MDC)