SummaryFor all NAKO study population deaths documented in the study research databank before November 30, 2024, sex, birth date, death date, first, eventual second and eventual third examination date, location/institution of death, region information as precise as possible shall be transmitted to the applicants. When available, all Frame A causes of death diagnoses (Part 1: the causal cascade from immediate cause of death to underlying cause; Part 2: other significant conditions contributing to death, but not resulting in the underlying cause given in Part 1) and all Frame B mortality information (surgery, autopsy, manner of death, place of occurrence, external agents, pregnancy, other), as collected in the NAKO Mortality-Follow-Up Modified and Extended Version of the “International Form of Medical Certificate of Cause of Death (WHO GENEVA 1979)”, shall also be transmitted to the applicants. The variable set shall be analyzed for a double purpose: I. Publishing a descriptive baseline-report describing the distribution of causes of death in the NAKO study population, checking for representativeness for the source population (residential population of Germany), and well known and newly detected biases. II. Comparing the information content and the added information value, respectively, of the three dimensions of the Frame A information in the NAKO Mortality-Follow-Up scheme: (a) original information on the death-certificate, (b) internally validated by the universally established cause-of-death coding software IRIS, and (c) externally validated by clinical, forensic, next-of-kin and other sources, according to the standards as described in the NAKO SOP Mortality-Follow-Up, main-authored by the main applicant of this data analysis project. Thus, this data analysis project also aims at a first comprehensive evaluation of the dimension (c), the innovative core of the NAKO Mortality-Follow-Up scheme.

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InstitutionsCenter for Population and Health - Medical School / Marburg University, Universitätsklinikum Heidelberg, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Deutsches Krebsforschungszentrum (DKFZ), Leibniz-Institut für Präventionsforschung und Epidemiologie - BIPS