SummaryBackground: The relationship between the local inflammatory effect of joint arthroplasty and systemic inflammatory processes is still not being thoroughly investigated in literature. This relationship may lead to several diseases such as sarcopenia, a condition characterized by loss of muscle mass, strength, and function in older adults. Progressive sarcopenia has been found to be directly associated with circulating inflammatory markers. Hypothesis: The current study aims to investigate the effect of endoprosthesis wear on sarcopenia in a cross-sectional study design. The following hypothesis was formulated: There is an association between wearing a joint endoprosthesis and higher levels of sarcopenia as measured by handgrip strength and lean appendicular muscle mass. Materials and Methods: Exposure (having a hip/knee endoprosthesis) and outcome (hand grip strength) will be analyzed. A generalized linear model will be constructed for analysis, adjusted for potential confounders.

Keywords Handgreifkraft Sarkopenie endoprosthesis grip-strength hand-grip hand-grip-forcing hip-replacement inflammatory-biomarkers joints knee-arthroplasty sarcopenia systemic-inflammation total-hip-replacement total-knee-arthroplasty

InstitutionsUniversitätsmedizin Greifswald, Universität Halle, Universitätsmedizin Rostock, Universitätsme, Deutsches Krebsforschungszentrum