SummaryBackground: The relationship between the local inflammatory effect of joint arthroplasty and systemic inflammatory processes is still being thoroughly investigated in the literature. It is also assumed that the systemic inflammatory process and the factors that contribute to low-grade chronic inflammation play an important role in the pathogenesis of various systemic diseases. Hypothesis: The current study aims to investigate the association between endoprosthesis wear and systemic inflammation processes in a cross-sectional study design. The following hypothesis was formulated: wearing of a joint endoprosthesis is associated with higher levels of systemic inflammation markers. Materials and Methods: Exposure (having hip/knee endoprostheses) and outcome (systemic inflammation (biomarkers)) will be analyzed. A generalized linear model will be constructed for analysis, adjusted for potential confounders.

Keywords CRP endoprosthesis hip-arthroplasty inflammatory-bio-markers joint-replacement joints knee-arthroplasty systemic-diseases systemic-inflammation total-hip-replacement total-knee-arthroplasty

InstitutionsUniversitätsmedizin Greifswald, Universitätsmedizin Rostock, Universitätsme, Leibniz-Institut für Präventionsforschung und Epidemiologie - BIPS