SummaryDue to demographic ageing and the rising prevalence of chronic conditions, multimorbidity is becoming a major public health challenge worldwide. The German National Cohort (NAKO) provides an unparalleled data source to examine the epidemiology of multimorbidity in Germany. Our project has a dual focus: (1) to describe the cross‐sectional distribution of multimorbidity—including both physical and mental health con-ditions—by age, sex, level of education, and migration background (differentiating first- and second-generation migrants as well as their different country/region of origin including Western, Eastern Europe, Turkish, resettlers and others from the autochthonous population), and (2) to explore longitudinal associa-tions between lifestyle risk factors (e.g. physical activity, diet, body mass index, smoking, and alcohol consumption) and the incidence and accumulation of chronic diseases. By integrating analyses of a com-prehensive list of up to 33 chronic conditions with a special emphasis on migrant populations, our study aims to address gaps in previous research and inform tailored public health strategies.

Keywords Multimorbidity risk-factors sociodemographic-determinants

InstitutionsStudienzentrum Berlin-Mitte (Charité), UKE Hamburg, Leibniz-Institut für Präventionsforschung und Epidemiologie - BIPS, Universitätsklinikum Heidelberg, DKFZ Heidelberg, Kompetenzzentrum Mortalitäts-Follow-UP, Netherlands Interdisciplinary Demographic Institute, The Hague, Netherlands, Charité-Universitätsmedizin Berlin, Charité - Universitätsmedizin Berlin